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One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce high protective levels of CD8+ T cells. These cells are crucial for protection against certain tumours and intracellular pathogens such as the liver-stage parasite of malaria. A liver-stage malaria vaccine should therefore include CD8+ T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD8+ T-cell responses against malaria with an emphasis on work from our laboratory. Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed.

Type

Journal article

Journal

Immunol Rev

Publication Date

08/1999

Volume

170

Pages

29 - 38

Keywords

Adjuvants, Immunologic, Animals, CD8-Positive T-Lymphocytes, Epitopes, Genetic Vectors, Humans, Immunization, Secondary, Malaria, Malaria Vaccines, Mice, Primates, Vaccines, DNA