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Obstruction of the microcirculation plays a central role in the pathophysiology of severe malaria. Here, Arjen Dondorp and colleagues describe the various contributors to impaired microcirculatory flow in falciparum malaria: sequestration, rosetting and recent findings regarding impaired red blood cell deformability. The correlation with clinical findings and possible therapeutic consequences are discussed.

Type

Journal article

Journal

Parasitol Today

Publication Date

06/2000

Volume

16

Pages

228 - 232

Keywords

Adult, Animals, Blood Flow Velocity, Child, Erythrocyte Deformability, Hemorheology, Humans, Malaria, Falciparum, Microcirculation, Plasmodium falciparum