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A 77G allele of the gene encoding CD45, also known as the protein tyrosine phosphatase receptor-type C gene (PTPRC), has been associated with multiple sclerosis (MS). Here we determine allele frequencies in large numbers of MS patients, primary immunodeficiencies linked to major histocompatibility complex (MHC) locus and over 1,000 controls to assess whether aberrant splicing of PTPRC caused by the 77C-->G polymorphism results in increased susceptibility to these diseases. Our results show no difference in the frequency of the 77G allele in patients and controls and thus do not support a causative role for the polymorphism in the development of disorders with a strong autoimmune component in etiology.

Original publication

DOI

10.1038/ng723

Type

Journal article

Journal

Nat Genet

Publication Date

09/2001

Volume

29

Pages

22 - 23

Keywords

Animals, Autoimmune Diseases, Chromosomes, Human, Pair 1, Genotype, Humans, Leukocyte Common Antigens, Major Histocompatibility Complex, Point Mutation, RNA Splicing