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ABSTRACT Immunization with DNA followed by modified vaccinia virus Ankara strain, both expressing the antigen 85A, induced both CD4 + - and CD8 + -T-cell responses in BALB/c mice. Following challenge with Mycobacterium tuberculosis , this prime-boost regimen produced protection equivalent to that conferred by Mycobacterium bovis BCG. Following immunization with dendritic cells pulsed with an antigen 85A CD4 + - or CD8 + -restricted epitope, alone or in combination, copresentation of both epitopes on the same dendritic cell was required for protection, demonstrating that induced CD8 + T cells can play a protective role against tuberculosis.

Original publication




Journal article


Infection and Immunity


American Society for Microbiology

Publication Date





1623 - 1626