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The Pneumonia Etiology Research for Child Health (PERCH) project is a 7-country, standardized, comprehensive evaluation of the etiologic agents causing severe pneumonia in children from developing countries. During previous etiology studies, between one-quarter and one-third of patients failed to yield an obvious etiology; PERCH will employ and evaluate previously unavailable innovative, more sensitive diagnostic techniques. Innovative and rigorous epidemiologic and analytic methods will be used to establish the causal association between presence of potential pathogens and pneumonia. By strategic selection of study sites that are broadly representative of regions with the greatest burden of childhood pneumonia, PERCH aims to provide data that reflect the epidemiologic situation in developing countries in 2015, using pneumococcal and Haemophilus influenzae type b vaccines. PERCH will also address differences in host, environmental, and/or geographic factors that might determine pneumonia etiology and, by preserving specimens, will generate a resource for future research and pathogen discovery.

Original publication

DOI

10.1093/cid/cir1052

Type

Journal article

Journal

Clin Infect Dis

Publication Date

04/2012

Volume

54 Suppl 2

Pages

S93 - 101

Keywords

Child Welfare, Child, Hospitalized, Child, Preschool, Data Collection, Developing Countries, Epidemiologic Research Design, Geography, Haemophilus Infections, Haemophilus influenzae type b, Humans, Infant, Pneumococcal Infections, Pneumonia, Risk Factors, Streptococcus pneumoniae