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Development of a vaccine against human immunodeficiency virus type 1 (HIV-1) is the main hope for controlling the acquired immunodeficiency syndrome pandemic. An ideal HIV vaccine should induce neutralizing antibodies, CD4+ helper T cells, and CD8+ cytotoxic T cells. While the induction of broadly neutralizing antibodies remains a highly challenging goal, there are a number of technologies capable of inducing potent cell-mediated responses in animal models, which are now starting to be tested in humans. Naked DNA immunization is one of them. This review focuses on the stimulation of HIV-specific T cells and discusses in the context of the current 'state-of-art' of DNA vaccines, the areas where this technology might assist either alone or as a part of more complex vaccine formulations in the HIV vaccine development.

Original publication




Journal article


Immunol Rev

Publication Date





144 - 155


AIDS Vaccines, Acquired Immunodeficiency Syndrome, Antigen Presentation, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, CpG Islands, HIV-1, Humans, Plasmids, Vaccines, DNA