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The leading blood-stage malaria vaccine candidate antigen, Plasmodium falciparum merozoite surface protein-1 (MSP-1) occurs in two major allelic types worldwide. The molecular basis promoting this stable dimorphism is unknown. In this study, we have shown that allelic altered peptide ligand (APL) T cell epitopes of MSP-1 mutually inhibited IFN-gamma secretion as well as proliferation of CD4+ T cells in 27/34 malaria exposed Gambian volunteers. Besides this inhibition of malaria-specific immunity, the same variant epitopes were also able to impair the priming of human T cells in malaria naive individuals. Epitope variants capable of interfering with T cell priming as well as inhibiting memory T cell effector functions offer a uniquely potent combination for immune evasion. Indeed, enhanced co-habitation of parasites bearing such antagonistic allelic epitope regions was observed in a study of 321 West African children, indicating a survival advantage for parasites able to engage this inhibitory immune interference mechanism.

Original publication

DOI

10.1002/eji.200526010

Type

Journal article

Journal

Eur J Immunol

Publication Date

05/2006

Volume

36

Pages

1168 - 1178

Keywords

Adolescent, Adult, Amino Acid Sequence, Animals, Epitopes, T-Lymphocyte, Humans, Immunologic Memory, Interferon-gamma, Lymphocyte Activation, Merozoite Surface Protein 1, Middle Aged, Molecular Sequence Data, Peptide Fragments, Plasmodium falciparum, T-Lymphocytes, Th1 Cells, Th2 Cells