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Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

Type

Journal article

Journal

Trends Parasitol

Publication Date

03/2004

Volume

20

Pages

109 - 112

Keywords

Animals, Antimalarials, Drug Combinations, Drug Resistance, Drug Synergism, Drug Therapy, Combination, Folic Acid, Folic Acid Antagonists, Malaria, Falciparum, Plasmodium falciparum, Probenecid, Pyrimethamine, Sulfadoxine