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We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P=.007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.

Original publication

DOI

10.1086/505875

Type

Journal article

Journal

J Infect Dis

Publication Date

01/09/2006

Volume

194

Pages

666 - 669

Keywords

Chemokine CCL5, Cohort Studies, HIV Seronegativity, HIV Seropositivity, Homozygote, Humans, Polymorphism, Genetic, Regression Analysis, Survival Analysis, Treatment Outcome, Uganda