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Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.

Original publication

DOI

10.1038/nm.1850

Type

Journal article

Journal

Nat Med

Publication Date

08/2008

Volume

14

Pages

819 - 821

Keywords

Adenoviridae, Animals, Genetic Vectors, Immunoglobulin G, Malaria, Malaria Vaccines, Mice, Mice, Inbred BALB C, Plasmodium falciparum, Plasmodium yoelii, Poxviridae, T-Lymphocytes, Vaccines, Vaccines, Subunit, Viral Vaccines