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The population of the Top End of the Northern Territory has a high incidence of several infections of particular significance in the immunosuppressed. The following protocol for evaluation and treatment of patients prior to immunosuppression was developed in order to reduce the incidence of serious opportunistic infections. The infections discussed are Strongyloides stercoralis, tuberculosis, scabies, chronic hepatitis B, melioidosis and other bacterial infections. We recommend that all patients planned to receive more than 0.5 mg/kg/day of prednisolone for >14 days, or any more potent immunosuppressive drug, be evaluated and treated according to this protocol. Details of the rationale, evidence base, and proposed investigations and therapy for such patients are discussed.

Type

Journal article

Journal

Commun Dis Intell Q Rep

Publication Date

2003

Volume

27

Pages

526 - 532

Keywords

AIDS-Related Opportunistic Infections, Bacteremia, Hepatitis B, Humans, Immunocompromised Host, Incidence, Northern Territory, Practice Guidelines as Topic, Scabies, Strongyloidiasis, Tropical Climate, Tuberculosis