Location of RNase and RNase inhibitor on free cytoplasmic mRNA-protein particles from human placenta.
Gileadi O., Lorberboum H., de Groot N., Hochberg AA.
Free cytoplasmic mRNPs were isolated from human placenta. An activity of RNase was associated with these particles but was mostly inhibited by a labile protein inhibitor. Both RNase and RNase inhibitor were extractable from mRNPs by 0.5 M KCl. The nature of the association of the RNase-RNase inhibitor complex with mRNPs makes it suitable as a putative system for control of expression and turnover of mRNPs and therefore of protein synthesis.