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The identification of large numbers of candidates genes and the introduction of methodologies for whole-genome screening have provided new opportunities for elucidating the molecular basis of variable susceptibility to major infectious diseases. 12 genes have been implicated in variable susceptibility to malaria and susceptibility/resistance genes for several other infectious diseases are beginning to be identified. Recent work suggests that large-scale family linkage and population association studies will be a more successful route to human disease genes than extrapolation from mouse models of infection.

Type

Journal article

Journal

Curr Opin Genet Dev

Publication Date

06/1996

Volume

6

Pages

348 - 353

Keywords

Animals, Communicable Diseases, Genetic Linkage, Humans, Immunity, Innate