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Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.

Original publication

DOI

10.1038/nbt1197-1280

Type

Journal article

Journal

Nat Biotechnol

Publication Date

11/1997

Volume

15

Pages

1280 - 1284

Keywords

Amino Acid Sequence, Animals, Epitopes, Female, Humans, Malaria Vaccines, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Plasmodium berghei, Plasmodium falciparum, T-Lymphocytes, Cytotoxic