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A longitudinal study of the CD8+ TCR variable (Vbeta) chain repertoire was performed in rhesus macaques experimentally infected with simian immunodeficiency virus (SIV) using both TCR Vbeta chain-specific monoclonal antibodies and TCR beta chain CDR3 length analysis. Expansions of subpopulations of CD8+ T cells were detected during the acute phase of SIV infection. In all monkeys studied, monoclonal expansions persisted for at least 18 months and increasingly dominated the repertoire of CD8+ T cells expressing the relevant Vbeta chain. This study shows that persistent CD8+ T cell expansions develop in response to a virus infection. This is important not only for our understanding of the T cell response to viruses but also for understanding the factors that determine the normal CD8+ TCR repertoire.

Original publication




Journal article


Eur J Immunol

Publication Date





1172 - 1180


Animals, Antibodies, Monoclonal, CD8-Positive T-Lymphocytes, Cell Differentiation, Clone Cells, Receptors, Antigen, T-Cell, alpha-beta, Simian Acquired Immunodeficiency Syndrome, Simian Immunodeficiency Virus, T-Lymphocyte Subsets