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To prevent duplication or loss of genomic regions during DNA replication, it is essential that the entire genome is copied precisely once every S phase. Cells achieve this by mutually exclusive regulation of origin firing and licensing. A crucial protein that is involved in origin licensing is chromatin licensing and DNA replication factor 1 (CDT1) and, therefore, activity of this protein must be strictly controlled. Four recent articles have demonstrated that proliferating cell nuclear antigen (PCNA), an essential sliding clamp used in replication and DNA repair, has a crucial role in this process by mediating the proteasomal degradation of CDT1.

Original publication




Journal article


Trends Mol Med

Publication Date





455 - 458


Animals, Cell Cycle, Cell Cycle Proteins, DNA Damage, DNA-Binding Proteins, Humans, Models, Biological, Proliferating Cell Nuclear Antigen, Proteasome Endopeptidase Complex, Xenopus Proteins