Early and nonreversible decrease of CD161++/MAIT cells in HIV infection
Cosgrove C., Ussher JE., Rauch A., Gärtner K., Kurioka A., Hühn MH., Adelmann K., Kang Y-H., Fergusson JR., Simmonds P., Goulder P., Hansen TH., Fox J., Günthard HF., Khanna N., Powrie F., Steel A., Gazzard B., Phillips RE., Frater J., Uhlig H., Klenerman P.
Key PointsThe frequency of CD161++ MAIT cells is dramatically decreased in the blood of HIV-infected patients, and they are nonrecoverable with HAART. Gut sequestration and apoptosis in response to bacterial signals may, amongst others, be mechanisms that contribute to this.