The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains
Hay D., Fedorov O., Filippakopoulos P., Martin S., Philpott M., Picaud S., Hewings DS., Uttakar S., Heightman TD., Conway SJ., Knapp S., Brennan PE.
Simple 1-substituted 5- and 6-isoxazolyl-benzimidazoles have been shown to be potent inhibitors of the BET bromodomains with selectivity over the related bromodomain of CBP.