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Africa carries the greatest burden of disease caused by Plasmodium falciparum, and we can expect this burden to rise in the near future, mainly because of drug resistance. Although effective drugs are available (such as artemether-lumefantrine, mefloquine, atovaquone-proguanil and halofantrine) they are uniformly too expensive for routine use. Affordable options include chloroquine plus sulfadoxine-pyrimethamine (SP), amodiaquine (alone or in combination with SP) and chlorproguanil-dapsone. Artemisinin combination therapy may offer considerable advantages over alternative therapies, but its introduction faces considerable logistic difficulty.

Type

Journal article

Journal

Microbes Infect

Publication Date

02/2002

Volume

4

Pages

157 - 164

Keywords

Africa, Animals, Antimalarials, Culicidae, Disease Vectors, Drug Resistance, Health Policy, Humans, Malaria, National Health Programs, Plasmodium falciparum, World Health Organization