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Exoantigens of Plasmodium vivax-parasitized erythrocytes stimulated macrophages to secrete tumor necrosis factor, and antisera raised against the exoantigens inhibited this secretion. The antisera also inhibited the activity of Plasmodium falciparum and Plasmodium yoelii exoantigens, and conversely, antisera against the latter cross-reacted with the exoantigens of P. vivax.



Publication Date





1241 - 1243


Department of Immunology, University College and Middlesex School of Medicine, London, United Kingdom.


Animals, Humans, Plasmodium falciparum, Plasmodium vivax, Tumor Necrosis Factor-alpha, Immune Sera, Antigens, Protozoan