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The relationship of the platelet-mediated autoagglutination of Plasmodium falciparum-infected red blood cells (IRBCs) to disease severity was investigated in 182 Thai patients with falciparum malaria; it was evident in 43% of uncomplicated malaria (n=63), 41% of severe malaria (n=104), and 100% of cerebral malaria (n=15; P=.001) isolates. The median (range) number of IRBCs in agglutinates per 1000 IRBCs was significantly higher in cerebral malaria (6 [3-42]) than in severe (0 [0-52]) and uncomplicated (0 [0-24]) malaria (P=.01). In multivariate analyses, high parasitemia and cerebral malaria were associated independently with parasite agglutination.

Original publication

DOI

10.1086/381900

Type

Journal article

Journal

J Infect Dis

Publication Date

15/03/2004

Volume

189

Pages

1052 - 1055

Keywords

Adult, Agglutination, Blood Platelets, CD36 Antigens, Erythrocyte Aggregation, Erythrocytes, Humans, Malaria, Falciparum, Rosette Formation, Severity of Illness Index