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Ferguson et al. (2013) use applied physics to quantitate the fitness of HIV-1 Gag based on sequence variability across the protein. This enables a new approach to vaccine design that focuses CD8+ T cell responses on fitness-constrained parts of Gag.

Original publication

DOI

10.1016/j.immuni.2013.02.017

Type

Journal article

Journal

Immunity

Publication Date

21/03/2013

Volume

38

Pages

410 - 413