Limited Polymorphism in the Dihydropteroate Synthetase Gene (dhps) of Plasmodium vivax Isolates from Thailand
Imwong M., Pukrittayakamee S., Cheng Q., Moore C., Looareesuwan S., Snounou G., White NJ., Day NPJ.
<jats:title>ABSTRACT</jats:title> <jats:p>The <jats:italic>dhps</jats:italic> sequences of 55 <jats:italic>Plasmodium vivax</jats:italic> isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pv<jats:italic>dhps</jats:italic> at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of Pv<jats:italic>dhps</jats:italic> and Pv<jats:italic>dhfr</jats:italic> were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.</jats:p>