Limited Polymorphism in the Dihydropteroate Synthetase Gene ( dhps ) of Plasmodium vivax Isolates from Thailand
Imwong M., Pukrittayakamee S., Cheng Q., Moore C., Looareesuwan S., Snounou G., White NJ., Day NPJ.
ABSTRACT The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pv dhps at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of Pv dhps and Pv dhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.