Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria.
Bright AT., Alenazi T., Shokoples S., Tarning J., Paganotti GM., White NJ., Houston S., Winzeler EA., Yanow SK.
Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.