Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis.
Mai NTH., Tuan TV., Wolbers M., Hoang DM., Nga TVT., Chau TTH., Chuong LV., Sinh DX., Nghia HDT., Phong ND., Phu NH., Diep TS., Hang HTT., Chau NVV., Farrar J., Schultsz C., Hien TT., Simmons CP.
Adjunctive treatment to improve outcome from bacterial meningitis has centered on dexamethasone. Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF:plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo.