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Ex vivo antimalarial sensitivity testing in human malaria parasites has largely depended on microscopic determination of schizont maturation. While this microscopic method is sensitive, it suffers from poor precision and is laborious. The recent development of portable, low-cost cytometers has allowed us to develop and validate a simple, field-optimized protocol using SYBR green and dihydroethidium for the accurate and objective determination of antimalarial drug sensitivity in freshly isolated Plasmodium vivax and Plasmodium falciparum.

Original publication

DOI

10.1128/AAC.00682-13

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

10/2013

Volume

57

Pages

5170 - 5174

Keywords

Antimalarials, Flow Cytometry, Plasmodium falciparum, Plasmodium vivax