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Human peripheral blood lymphocytes have been sensitized in vitro to influenza virus antigen. After an induction period of 4--14 days, cytotoxic cells which lyse autologous influenza virus-infected lymphoid cells could be demonstrated. The cytotoxic cell is a T lymphocyte which shows specificity for sensitizing influenza virus type A or B. It cannot distinguish between major subtypes of influenza A virus. The use of virus-infected normal lymphoid cells as target cells overcame the difficulties of nonspecific killing encountered with some transformed cells.

Original publication




Journal article


Eur J Immunol

Publication Date





705 - 711


Cytotoxicity Tests, Immunologic, Cytotoxicity, Immunologic, Humans, Influenza A virus, Kinetics, Seasons, T-Lymphocytes