Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
Thompson AAR., Elks PM., Marriott HM., Eamsamarng S., Higgins KR., Lewis A., Williams L., Parmar S., Shaw G., McGrath EE., Formenti F., Van Eeden FJ., Kinnula VL., Pugh CW., Sabroe I., Dockrell DH., Chilvers ER., Robbins PA., Percy MJ., Simon MC., Johnson RS., Renshaw SA., Whyte MKB., Walmsley SR.
Key PointsNeutrophil lifespan is extended in patients with gain-of-function HIF2A mutations. HIF-2α regulates in vivo neutrophil longevity and thus tissue inflammation and repair.