SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage
Clifford R., Louis T., Robbe P., Ackroyd S., Burns A., Timbs AT., Wright Colopy G., Dreau H., Sigaux F., Judde JG., Rotger M., Telenti A., Lin Y-L., Pasero P., Maelfait J., Titsias M., Cohen DR., Henderson SJ., Ross MT., Bentley D., Hillmen P., Pettitt A., Rehwinkel J., Knight SJL., Taylor JC., Crow YJ., Benkirane M., Schuh A.
Key Points Acquired pathogenic mutations in SAMHD1 are found in up to 11% of relapsed/refractory patients with CLL. SAMHD1 is mobilized to sites of DNA damage.