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Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The present review surveys recent data on the structure and regulation of sGC, and the prospects of new avenues for therapeutic intervention.

Original publication

DOI

10.1042/BST20130228

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

02/2014

Volume

42

Pages

108 - 113

Keywords

Allosteric Regulation, Animals, Cardiovascular Diseases, Catalytic Domain, Drug Discovery, Guanylate Cyclase, Humans, Protein Structure, Secondary