Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine.
Jaroensuk J., Stoesser N., Leimanis ML., Jittamala P., White NJ., Nosten FH., McGready R.
Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns.