Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography
Guetzoyan L., Ingham RJ., Nikbin N., Rossignol J., Wolling M., Baumert M., Burgess-Brown NA., Strain-Damerell CM., Shrestha L., Brennan PE., Fedorov O., Knapp S., Ley SV.
Novel technologies were developed and used for the synthesis and evaluation of new triazolopyridazine BRD9 inhibitors.