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Malaria causes nearly 1 million deaths annually. Recent emergence of multidrug resistance highlights the need to develop novel therapeutic interventions against human malaria. Given the involvement of sugar binding plasmodial proteins in host invasion, we set out to identify such proteins as targets of small glycans. Combining multidisciplinary approaches, we report the discovery of a small molecule inhibitor, NIC, capable of inhibiting host invasion through interacting with a major invasion-related protein, merozoite surface protein-1 (MSP-1). This interaction was validated through computational, biochemical, and biophysical tools. Importantly, treatment with NIC prevented host invasion by Plasmodium falciparum and Plasmodium vivax--major causative organisms of human malaria. MSP-1, an indispensable antigen critical for invasion and suitably localized in abundance on the merozoite surface represents an ideal target for antimalarial development. The ability to target merozoite invasion proteins with specific small inhibitors opens up a new avenue to target this important pathogen.

Original publication

DOI

10.1093/infdis/jiu296

Type

Journal article

Journal

J Infect Dis

Publication Date

15/11/2014

Volume

210

Pages

1616 - 1626

Keywords

Plasmodium falciparum, Plasmodium vivax, chemical biology, glycan mimetic small molecules, host invasion, malaria, mass spectrometry, merozoite surface proteins, red blood cell, Antimalarials, Endocytosis, Humans, Merozoite Surface Protein 1, Plasmodium falciparum, Plasmodium vivax