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Reduced Plasmodium falciparum sensitivity to short-course artemisinin (ART) monotherapy manifests as a long parasite clearance half-life. We recently defined three parasite founder populations with long half-lives in Pursat, western Cambodia, where reduced ART sensitivity is prevalent. Using the ring-stage survival assay, we show that these founder populations have reduced ART sensitivity in vitro at the early ring stage of parasite development and that a genetically admixed population contains subsets of parasites with normal or reduced ART sensitivity.

Original publication

DOI

10.1128/AAC.03055-14

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

08/2014

Volume

58

Pages

4935 - 4937

Keywords

Alleles, Antimalarials, Artemisinins, Cambodia, Drug Resistance, Founder Effect, Half-Life, Humans, Life Cycle Stages, Malaria, Falciparum, Mutation, Parasitic Sensitivity Tests, Plasmodium falciparum