Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Endothelial nitric oxide (NO) bioavailability, microvascular function, and host oxygen consumption have not been assessed in pediatric malaria. We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyperemia index (RHI), and microvascular function and oxygen consumption (VO2) using near infrared resonance spectroscopy in 13 Indonesian children with severe falciparum malaria and 15 with moderately severe falciparum malaria. Compared with 19 controls, children with severe malaria and those with moderately severe malaria had lower RHIs (P = .03); 12% and 8% lower microvascular function, respectively (P = .03); and 29% and 25% higher VO2, respectively. RHIs correlated with microvascular function in all children with malaria (P < .001) and all with severe malaria (P < .001). Children with malaria have decreased endothelial and microvascular function and increased oxygen consumption, likely contributing to the pathogenesis of the disease.

Original publication

DOI

10.1093/infdis/jiu308

Type

Journal article

Journal

J Infect Dis

Publication Date

15/11/2014

Volume

210

Pages

1627 - 1632

Keywords

Plasmodium falciparum, cerebral malaria, endothelial function, microvascular function, oxygen consumption, severe malaria, tissue hypoxia, Animals, Child, Child, Preschool, Endothelial Cells, Female, Humans, Malaria, Falciparum, Male, Microvessels, Nitric Oxide, Oxygen Consumption, Spectroscopy, Near-Infrared