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ABSTRACT Human metapneumovirus is a major cause of respiratory tract infections worldwide. Previous reports have shown that the viral attachment glycoprotein (G) modulates innate and adaptive immune responses, leading to incomplete immunity and promoting reinfection. Using bioinformatics analyses, static light scattering, and small-angle X-ray scattering, we show that the extracellular region of G behaves as a heavily glycosylated, intrinsically disordered polymer. We discuss potential implications of these findings for the modulation of immune responses by G.

Original publication

DOI

10.1128/jvi.01726-14

Type

Journal article

Journal

Journal of Virology

Publisher

American Society for Microbiology

Publication Date

10/2014

Volume

88

Pages

11611 - 11616