Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The ability of stem cells to self-renew and generate different lineages during development and organogenesis is a fundamental, tightly controlled, and generally unidirectional process, whereas the 'immortality' of cancer cells could be regarded as pathological self-renewal. The molecular mechanisms that underpin the generation of induced pluripotent stem cells are remarkably similar to those that are deregulated in cancer - so much so that aberrant reprogramming is tumorigenic. The similarities also suggest that mutations in genes implicated in DNA methylation dynamics might represent a hallmark of cancers with a stem cell origin, and they highlight an alternative view of cancer that may be of clinical benefit.

Original publication

DOI

10.1038/nrc3781

Type

Journal article

Journal

Nat Rev Cancer

Publication Date

08/2014

Volume

14

Pages

568 - 573

Keywords

Animals, Cell Transformation, Neoplastic, Cellular Reprogramming, DNA (Cytosine-5-)-Methyltransferases, Epigenesis, Genetic, Humans, Isocitrate Dehydrogenase, Neoplasms, Proto-Oncogene Proteins, Tumor Microenvironment