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Liposomal amphotericin-B (AmBisome) is now becoming first choice for the treatment of visceral leishmaniasis (kala-azar) patients due to high efficacy and less toxicity. The reported incidence of hypersensitivity reactions to liposomal amphotericin-B (AmBisome), especially during therapy, is very rare. We report two patients with kala-azar: one developed breathing difficulties and hypotension followed by shock and the other had facial angioedema with chest tightness during treatment. Both patients were managed with immediate action of injection: adrenaline, diphenhydramine and hydrocortisone. In our experience, AmBisome can cause severe hypersensitivity reactions that warrant proper support and close supervision.

Original publication




Journal article


Trop Doct

Publication Date





241 - 242


AmBisome, Leishmaniasis, Adult, Amphotericin B, Bangladesh, Child, Diphenhydramine, Emergencies, Epinephrine, Female, Humans, Hydrocortisone, Hypersensitivity, Immediate, Leishmaniasis, Visceral, Male