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There are few studies that have examined the frequencies of epitope-specific CD4(+) T cells following the use of a highly effective vaccine, yet such data would potentially be of value for the development of novel vaccination strategies. In this study we tracked human epitope-specific CD4(+) T cell responses over time after immunisation with a live attenuated varicella zoster virus vaccine by MHC Class II tetrameric complexes and functional assays. We show that the peptide-specific responses reflect those against whole virus antigens, and are similar in both frequency and phenotype to those found in healthy volunteers, despite a highly attenuated and clinically inapparent infection.

Original publication




Journal article



Publication Date





7398 - 7401


Adult, Antibodies, Viral, Antigens, Viral, CD4-Positive T-Lymphocytes, Chickenpox, Chickenpox Vaccine, Epitopes, T-Lymphocyte, Female, HLA-DR Antigens, HLA-DRB1 Chains, Health Personnel, Humans, Immunity, Cellular, Immunoglobulin G, Interferon-gamma, Leukocytes, Mononuclear, Male, Middle Aged, Vaccines, Attenuated, Young Adult