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A potent inhibitor of the JmjC histone lysine demethylase KDM2A (compound 35, pIC50 7.2) with excellent selectivity over representatives from other KDM subfamilies has been developed; the discovery that a triazolopyridine compound binds to the active site of JmjC KDMs was followed by optimisation of the triazole substituent for KDM2A inhibition and selectivity.

Original publication

DOI

10.1039/C4MD00291A

Type

Journal article

Journal

Medchemcomm

Publication Date

01/12/2014

Volume

5

Pages

1879 - 1886