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We introduce a new method for estimating recombination rates from population genetic data. The method uses a computationally intensive statistical procedure (importance sampling) to calculate the likelihood under a coalescent-based model. Detailed comparisons of the new algorithm with two existing methods (the importance sampling method of Griffiths and Marjoram and the MCMC method of Kuhner and colleagues) show it to be substantially more efficient. (The improvement over the existing importance sampling scheme is typically by four orders of magnitude.) The existing approaches not infrequently led to misleading results on the problems we investigated. We also performed a simulation study to look at the properties of the maximum-likelihood estimator of the recombination rate and its robustness to misspecification of the demographic model.

Type

Journal article

Journal

Genetics

Publication Date

11/2001

Volume

159

Pages

1299 - 1318

Keywords

Genetics, Population, Likelihood Functions, Microsatellite Repeats, Models, Genetic, Models, Statistical, Models, Theoretical, Monte Carlo Method, Recombination, Genetic