Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The development of safe and effective vaccines for cancer and infectious diseases remains a major goal in public health. Over the last two decades, controlled release of vaccine antigens and immunostimulant molecules has been achieved using nanometer or micron-sized delivery vehicles synthesized using biodegradable polymers. In addition to achieving a depot effect, enhanced vaccine efficacy using such delivery vehicles has been attributed to efficient targeting of antigen presenting cells such as dendritic cells. Biodegradable and biocompatible poly(lactic acid) and poly(lactic-co-glycolic acid) polymers belong to one such family of polymers that have been a popular choice of material used in the design of these delivery vehicles. This review summarizes research findings from ourselves and others highlighting the promise of poly(lactic acid)- and poly(lactic-co-glycolic acid)-based vaccine carriers in enhancing immune responses.

Original publication

DOI

10.2217/nnm.14.156

Type

Journal article

Journal

Nanomedicine (Lond)

Publication Date

12/2014

Volume

9

Pages

2703 - 2718

Keywords

PLA, PLGA, adjuvants, biodegradable, controlled release, immune response, particles, vaccine delivery, Adjuvants, Immunologic, Antigens, Dendritic Cells, Drug Carriers, Drug Delivery Systems, Humans, Immunity, Cellular, Lactic Acid, Microspheres, Polyesters, Polyglycolic Acid, Polylactic Acid-Polyglycolic Acid Copolymer, Polymers, Vaccines