Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function
Lakhal-Littleton S., Wolna M., Carr CA., Miller JJJ., Christian HC., Ball V., Santos A., Diaz R., Biggs D., Stillion R., Holdship P., Larner F., Tyler DJ., Clarke K., Davies B., Robbins PA.
Significance The iron-exporting protein ferroportin is recognized as central to systemic iron regulation, but its role in tissues other than those involved in iron handling is unknown. This study shows that ferroportin expression in cardiomyocytes is essential to intracellular iron homeostasis and to normal cardiac function. It also demonstrates that the site of iron accumulation in the iron-overloaded heart depends on whether ferroportin is expressed in the cardiomyocytes. It further shows that the functional significance of cardiac iron overload is highly dependent upon the site of iron accumulation. These findings change our understanding of intracellular iron homeostasis and have significant implications for the clinical management of cardiac dysfunction associated with iron imbalance.