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Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnostic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptibility testing results. Field diagnosis combined with centralized molecular resistance testing could improve typhoid management and surveillance in low-resource settings.

Original publication

DOI

10.1128/JCM.00531-15

Type

Journal article

Journal

J Clin Microbiol

Publication Date

05/2015

Volume

53

Pages

1758 - 1760

Keywords

Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bacteriological Techniques, Child, Child, Preschool, DNA Gyrase, DNA, Bacterial, Diagnostic Tests, Routine, Drug Resistance, Bacterial, Female, Fluoroquinolones, Humans, Infant, Infant, Newborn, Male, Middle Aged, Molecular Diagnostic Techniques, Pilot Projects, Polymerase Chain Reaction, Prospective Studies, Salmonella typhi, Time Factors, Typhoid Fever, Young Adult