Plasmodium vivax susceptibility to ferroquine.
Leimanis ML., Jaidee A., Sriprawat K., Kaewpongsri S., Suwanarusk R., Barends M., Phyo AP., Russell B., Renia L., Nosten F.
The novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquine-resistant Plasmodium falciparum. The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P. vivax schizont maturation (median 50% inhibitory concentration, 15 nM; n = 42). No significant cross-sensitivity between ferroquine and other antimalarials was detected. This drug may be a suitable replacement for chloroquine in the treatment of drug-resistant P. vivax malaria.