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The novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquine-resistant Plasmodium falciparum. The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P. vivax schizont maturation (median 50% inhibitory concentration, 15 nM; n = 42). No significant cross-sensitivity between ferroquine and other antimalarials was detected. This drug may be a suitable replacement for chloroquine in the treatment of drug-resistant P. vivax malaria.

Original publication

DOI

10.1128/AAC.01572-09

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

05/2010

Volume

54

Pages

2228 - 2230

Keywords

Aminoquinolines, Antimalarials, Dose-Response Relationship, Drug, Drug Resistance, Bacterial, Ferrous Compounds, Humans, In Vitro Techniques, Malaria, Vivax, Microbial Sensitivity Tests, Plasmodium vivax, Thailand