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© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. Objectives: Protection against HIV type 1 (HIV-1) infection/AIDS will likely require concerted actions of protective CD8+killer T cells and protective antibodies. The challenges in inducing such effectors by active immunization are such that the T-cell and antibody vaccine components require separate development. Here, a rational attempt is taken to combine two separately optimized heterologous regimens into a single T-cell-inducing and antibody-inducing vaccination schedule with minimal induction of unprotective Env-specific T cells.

Original publication

DOI

10.1097/QAD.0000000000000468

Type

Journal article

Journal

AIDS

Publication Date

01/01/2014

Volume

28

Pages

2495 - 2504