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Patients with inherited deficiency of the interleukin (IL)-12/IL-23-interferon (IFN)- gamma axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/IL-23-component deficiency had a history of salmonella disease than did those with IFN- gamma -component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings strongly suggest that IL-12/IL-23 is a key cytokine for immunity against salmonella in humans and that IL-12/IL-23 mediates this protective effect partly through IFN- gamma -independent pathways. Investigation of the IL-12/IL-23-IFN- gamma axis should be considered in patients with invasive salmonella disease.

Original publication

DOI

10.1086/425021

Type

Conference paper

Publication Date

15/11/2004

Volume

190

Pages

1755 - 1757

Keywords

Adolescent, Adult, Child, Child, Preschool, Female, Genetic Predisposition to Disease, Humans, Infant, Interferon-gamma, Interleukin-12, Interleukin-23, Interleukin-23 Subunit p19, Interleukins, Male, Middle Aged, Salmonella, Salmonella Infections