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Plasmodium vivax is the major species of malaria parasite outside Africa. It is especially problematic in that the infection can relapse in the absence of mosquitoes by activation of dormant hypnozoites in the liver. Medicines that target the erythrocytic stages of Plasmodium falciparum are also active against P. vivax, except where these have been compromised by resistance. However, the only clinical therapy against relapse of vivax malaria is the 8-aminoquinoline, primaquine. This molecule has the drawback of causing haemolysis in genetically sensitive patients and requires 14 days of treatment. New, safer and more-easily administered drugs are urgently needed, and this is a crucial gap in the broader malaria-elimination agenda. New developments in cell biology are starting to open ways to the next generation of drugs against hypnozoites. This search is urgent, given the time needed to develop a new medication.

Original publication

DOI

10.1016/j.pt.2009.12.005

Type

Journal article

Journal

Trends Parasitol

Publication Date

03/2010

Volume

26

Pages

145 - 151

Keywords

Animals, Antimalarials, Disease Reservoirs, Humans, Life Cycle Stages, Liver, Malaria, Plasmodium vivax