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The etiology of fever in rural Lao People's Democratic Republic (Laos) has remained obscure until recently owing to the lack of laboratory facilities. We conducted a study to determine the causes of fever among 229 patients without malaria in Savannakhet Province, southern Laos; 52% had evidence of at least one diagnosis (45% with single and 7% with apparent multiple infections). Among patients with only one diagnosis, dengue (30.1%) was the most common, followed by leptospirosis (7.0%), Japanese encephalitis virus infection (3.5%), scrub typhus (2.6%), spotted fever group infection (0.9%), unspecified flavivirus infection (0.9%), and murine typhus (0.4%). We discuss the empirical treatment of fever in relation to these findings.

Original publication




Journal article


Am J Trop Med Hyg

Publication Date





517 - 520


Adolescent, Adult, Aged, Aged, 80 and over, Boutonneuse Fever, Child, Child, Preschool, Dengue, Encephalitis, Japanese, Female, Fever, Flavivirus Infections, Humans, Infant, Laos, Leptospirosis, Male, Middle Aged, Rural Population, Scrub Typhus, Young Adult