Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A region 2 kb upstream of exon 1 of the P2X7 gene was sequenced using DNA from nine healthy individuals who exhibited three different ATP response phenotypes (i.e. high, low and interferon gamma-inducible). Five single nucleotide polymorphisms were identified within the nine donor promoter sequences but none were associated with a specific ATP response phenotype. A P2X7 loss of function polymorphism (1513 in exon 13) was also screened for within donor DNA but no response associations were identified. ATP response phenotype was positively associated with P2X(7) receptor expression, as assessed by flow cytometry, but not with any identified receptor or promoter gene polymorphisms.


Journal article



Publication Date





127 - 131


Adenosine Triphosphate, Base Sequence, Cells, Cultured, Humans, Interferon-gamma, Macrophages, Molecular Sequence Data, Phenotype, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, RNA, Messenger, Receptors, Purinergic P2, Receptors, Purinergic P2X7, Sequence Alignment, Transcription, Genetic